Posttreatment human papillomavirus testing for recurrent cervical intraepithelial neoplasia: a systematic review - 13/08/11
, Christina A. Slee, MPH c, Rose Arellanes, MD d, George F. Sawaya, MD e
Reprints: Joy Melnikow, MD, MPH, Department of Family and Community Medicine, University of California, Davis, 4860 Y St, Suite 2300, Sacramento, CA 95817Résumé |
Objective |
We conducted a systematic review to evaluate the characteristics of human papillomavirus testing, particularly Hybrid Capture 2, in follow-up evaluations after treatment for cervical intraepithelial neoplasia for the detection of residual or recurrent cervical intraepithelial neoplasia grade ≥ 2.
Study Design |
Medline was searched for relevant studies that were published between 1992 and September 2007. Of the 1107 citations that were identified, 20 articles met the inclusion criteria.
Results |
Studies that used polymerase chain reaction testing were too heterogeneous to combine. We identified 5 studies that performed both Hybrid Capture 2 and colposcopy. Pooled sensitivity for Hybrid Capture 2 was 90.7% (95% CI, 75.4-96.9%), and pooled specificity was 74.6% (95% CI, 60.4-85.0%). Pooled sensitivity for cervical cytologic testing was 76.6% (95% CI, 62.0-86.8%), and pooled specificity was 89.7% (95% CI, 22.7-99.6%).
Conclusion |
Hybrid Capture 2 testing can identify approximately 91% of women with residual or recurrent cervical intraepithelial neoplasia grade ≥ 2; however, approximately 30% of women would undergo colposcopy in follow-up evaluation.
Le texte complet de cet article est disponible en PDF.Key words : cervical intraepithelial neoplasia, colposcopy, Hybrid Capture 2, metaanalysis, papillomavirus
Plan
| This research was supported by National Cancer Institute Grant 1R01CA109142. |
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| Authorship and contribution to the manuscript is limited to the 5 authors indicated. There was no outside funding or technical assistance with the production of this article. |
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| Cite this article as: Chan BKS, Melnikow J, Slee CA, Arellanes R, Sawaya GF. Posttreatment human papillomavirus testing for recurrent cervical intraepithelial neoplasia: a systematic review. Am J Obstet Gynecol 2009;200:422.e1-422.e9. |
Vol 200 - N° 4
P. 422.e1-422.e9 - avril 2009 Retour au numéro
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