Brain Cooling for Preterm Infants - 15/08/11
, Laura Bennet, PhD a
Corresponding author. Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.Abstract |
There is strong evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce neuronal loss and improve behavioral recovery in term infants and adults after cardiac arrest. This review examines the evidence that mild to moderate hypothermia is protective after hypoxia-ischemia in models of preterm brain injury and evaluates the potential risks. Induced hypothermia likely has potential to significantly reduce disability. Cautious, systematic trials are essential before hypothermia can be used in these vulnerable infants.
Le texte complet de cet article est disponible en PDF.Keywords : Therapeutic hypothermia, Fetal sheep, Preterm infant, Periventricular leukomalacia
Plan
| This work was supported by grants from the Health Research Council of New Zealand, the March of Dimes Birth Defects trust, the Auckland Medical Research Foundation, and Lottery Health New Zealand. |
Vol 35 - N° 4
P. 735-748 - décembre 2008 Retour au numéro
Article précédent
- Hypothermia for Hypoxic-Ischemic Encephalopathy
- Rakesh Sahni, Ulana M. Sanocka
- Supportive Care During Neuroprotective Hypothermia in the Term Newborn: Adverse Effects and Their Prevention
- Marianne Thoresen
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