Hypothermia as neuroprotective treatment requires significant knowledge of how temperature affects all organ systems and interventions used in intensive care. Education and training in resuscitation, including avoidance of hyperthermia, early diagnosis of eligible infants, and initiation of early cooling followed by safe transport of cooled infants to the cooling center seems to be an optimal approach. This article suggests clinical management and shows examples of potential adverse effects of clinical hypothermia. The practical cooling recommendations suggested herein are therefore likely to develop and change over time as more experience is gained.