Extremely Low Birthweight Neonates with Protracted Ventilation: Mortality and 18-Month Neurodevelopmental Outcomes - 15/08/11
, Brenda H. Morris, MD, Lisa A. Wrage, MPH, Betty R. Vohr, MD, W. Kenneth Poole, PhD, Jon E. Tyson, MD, MPH, Linda L. Wright, MD, Richard A. Ehrenkranz, MD, Barbara J. Stoll, MD, Avroy A. Fanaroff, MB, BChfor the National Institutes of Child Health and Human Development Neonatal Research Network
Reprint requests: Dr Michele C. Walsh, Rainbow Babies and Childrens Hospital, Mailstop 6010, 11100 Euclid Avenue, Cleveland OH 44106-6010.Abstract |
Objective |
To compare duration of ventilation to mortality and adverse neurodevelopmental outcomes among extremely low birth weight (ELBW; 501-1000 g) infants.
Study design |
Retrospective analysis of prospectively collected data from 5364 infants with a birthweight of 501 to 1000 g born at National Institute of Child Health and Human Development (NICHD) Neonatal Research Network centers from 1995 to 1998. The main outcome measures were: survival, duration of mechanical ventilation, and neurodevelopmental outcome.
Results |
Overall survival was 71%. The median duration of ventilation for survivors was 23 days; 75% were free of mechanical ventilation by 39 days, and 7% were ventilated for ≥60 days. Of those ventilated for ≥60 days, 24% survived without impairment. Of those ventilated for ≥90 days, only 7% survived without impairment. Of those ventilated ≥120 days, all survivors were impaired.
Conclusions |
The prognosis for ELBW with protracted ventilation remains grim. The cohort who remain intubated have diminished survival and high rates of impairment. Parents of these infants should be informed of changes in prognosis as the time of ventilation increases.
Le texte complet de cet article est disponible en PDF.Mots-clés : CPAP, ELBW, IVH, NICHD, SGA
Plan
Vol 146 - N° 6
P. 798-804 - juin 2005 Retour au numéro
Article précédent
- Satisfaction in Different Life Domains in Children Receiving Home Parenteral Nutrition and Their Families
- Frédéric Gottrand, Pierre Staszewski, Virginie Colomb, Irène Loras-Duclaux, Dominique Guimber, Evelyne Marinier, Anne Breton, Sabine Magnificat
- Endothelin-1 in Human Intestine Resected for Necrotizing Enterocolitis
- Philip T. Nowicki, David J. Dunaway, Craig A. Nankervis, Peter J. Giannnone, Kristina M. Reber, Susan B. Hammond, Gail E. Besner, Donna A. Caniano
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?