Specific allergic sensitization in parents and their 18-year-old offspring in the Suburban Detroit Childhood Allergy Study - 15/08/11
, Ganesa Wegienka, PhD b, Suzanne Havstad, MS b, Dennis R. Ownby, MD c, Christine Cole Johnson, PhD b, Edward M. Zoratti, MD a
Reprint requests: Rana T. Misiak, MD, Henry Ford Health System, One Ford Place 4B, Detroit MI 48202.Abstract |
Background |
Allergic sensitization is increased among offspring of sensitized parents.
Objective |
We sought to evaluate whether 18-year-old offspring are likely to have the same allergic sensitizations as their parents.
Methods |
Eighteen-year-old participants in an unselected birth cohort and their parents were tested for total and increased (>0.35 kU/L) levels of allergen-specific IgE to 6 allergens: Dermatophagoides farinae, dog, cat, grass, ragweed, and Alternaria alternata.
Results |
In 316 parent-teen triads parental sensitization to any of 6 allergens was associated with teen sensitization to any of those same allergens. An increased risk of matched sensitization (ie, a teen has an increased risk of being sensitized to the same specific allergen as their parent) was found after adjusting for the spouse’s sensitivities and adjusting for other allergens (ie, the parent had an allergic sensitization but not to the particular allergen under analysis). Risk of maternal matched sensitization with their teen to cat (adjusted odds ratio [aOR], 2.1; 95% CI, 1.0-4.5), grass (aOR, 2.5; 95% CI, 1.2-5.2), and A alternata (aOR, 2.4; 95% CI, 1.1-5.5) was increased when compared with that seen in teens without parental allergen-specific sensitization. Similarly, a higher than expected risk of paternal matched sensitization with their teen to dog (aOR, 2.7; 95% CI, 1.3-5.9), D farinae (aOR, 2.7; 95% CI, 1.4-5.1), and grass (aOR, 2.7; 95% CI, 1.5-5.9) was observed.
Conclusion |
Parental allergen-specific IgE increases the likelihood of sensitization to the same allergen in young adult offspring.
Le texte complet de cet article est disponible en PDF.Key word : Allergen-specific IgE
Abbreviations used : aOR, CAS, OR
Plan
| Supported by the National Institute of Allergy and Infectious Disease, the Fund for Henry Ford Hospital, and the Henry Ford Hospital Department of Medical Education Resident Research Award. |
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| Disclosure of potential conflict of interest: G. Wegienka receives grant support from the National Institutes of Health. D. R. Ownby receives grant support from the National Institutes of Health and is a study section member for the National Institutes of Health and a board member of the Merck Childhood Asthma Network. C. C. Johnson receives grant support from the National Institutes of Health. E. M. Zoratti receives grant support from the National Institute of Allergy and Infectious Diseases. The rest of the authors have reported that they have no conflict of interest. |
Vol 123 - N° 6
P. 1401 - juin 2009 Retour au numéro
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