The safety of patients receiving sedation and sedating analgesia therapies is a system property. There are multiple team members and processes needed to ensure safety that reside outside the purview of nursing. This article outlines safety considerations in sedation using the Eindhoven classification system as framework for aggregating contributing factors in error events into a useful format. Using this approach offers consistency in investigation and a framework for making sense of data. For this article, sedatives and analgesic medication related events are considered.