Opioids and central sensitisation: I. Pre-emptive analgesia - 15/08/11
Doi : 10.1016/j.ejpain.2004.05.012
Jürgen Sandkühler ⁎ 
, Ruth Ruscheweyh
, Ruth Ruscheweyh Department of Neurophysiology, Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria
⁎Corresponding author. Tel.: +43 1 4277 628 34/35; fax: +43 1 4277 628 65
Abstract |
Opioids are powerful analgesics when used to treat acute pain and some forms of chronic pain. A large body of literature has shown that opioids can, in addition, also prevent (this review) or induce and perhaps reverse [Ruscheweyh and Sandkühler, Eur. J. Pain, in press, doi:10.1016/j.ejpain.2004.05.011] some forms central sensitisation in in vitro and in vivo animal models of pain. However, the concept of central sensitisation is, at present, ambiguous and the usefulness of opioids as pre-emptive analgesics in human pain patients is still not clear.
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© 2004
European Federation of Chapters of the International Association for the Study of Pain. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 9 - N° 2
P. 145-148 - avril 2005 Retour au numéro
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- Ruth Ruscheweyh, Jürgen Sandkühler
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