Detecting, Studying, and Treating Autism Early: The One-Year Well-Baby Check-Up Approach - 15/08/11
, Cindy Carter, PhD a, b, Melanie Weinfeld, PhD a, b, Jamie Desmond, MPH b, Roxana Hazin, BS b, Robert Bjork, MD c, Nicole Gallagher, BA b
Reprint requests: Karen Pierce, PhD, Department of Neurosciences, Autism Center of Excellence, UCSD, 8110 La Jolla Shores Dr, La Jolla, CA, 92037.Abstract |
Objectives |
To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD).
Study design |
The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation.
Results |
Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of “other.” Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75.
Conclusions |
The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
Le texte complet de cet article est disponible en PDF.Mots-clés : ADOS-T, ASD, CSBS-DP-IT-Checklist, LD, DD
Plan
| Supported by Organization for Autism Research, Autism Speaks (formerly Cure Autism Now), and NIMH (R01-MH080134 to K.P). The authors declare no conflicts of interest. |
Vol 159 - N° 3
P. 458 - septembre 2011 Retour au numéro
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