Rapid Fluid Resuscitation in Pediatrics: Testing the American College of Critical Care Medicine Guideline - 15/08/11

Résumé |
Study objective |
The 2002 American College of Critical Care Medicine (ACCM) guidelines for the resuscitation of pediatric septic shock suggest that 20 mL/kg of bolus intravenous fluid be given within 5 minutes. Of 3 commonly used, inexpensive methods of fluid delivery, we hypothesized that only use of a manual push-pull system will permit guideline adherence.
Methods |
This prospective, interventional study was open to children in the Columbus Children’s Hospital Emergency Department who were ordered a 20 mL/kg nonemergent fluid bolus by their treating physician. Subjects were randomized to receive the fluid for 5 minutes by a pressure bag maintained at 300 mm Hg, by a manual push-pull system, or by gravity. Volume of fluid delivered, absolute rates of fluid delivery, and adherence to the ACCM guideline were recorded. Statistical analysis was done with both parametric and nonparametric methods.
Results |
Sixty children were enrolled, with 57 included in data analysis. Median volumes of fluid delivered in the study period were 20.9 mL/kg (pressure bag), 20.2 mL/kg (push-pull), and 6.2 mL/kg (gravity) (P<.0001). The ACCM guideline was met in 58% of the pressure bag group, 68% of the push-pull group, and none of the gravity group. No children weighing greater than 40 kg met the guideline in any of the groups.
Conclusion |
The ACCM guideline for rapid fluid resuscitation is feasible for many children, especially those weighing less than 40 kg. Contrary to our hypothesis, the use of a pressure bag and a manual push-pull system both appear to be acceptable methods of rapid fluid delivery. Administration of bolus fluid by gravity likely has a limited role in acute pediatric resuscitation.
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| Supervising editor: Kathy N. Shaw, MD, MSCE Author contributions: MJS and MWH conceived of the study. MJS, DGG, DMC, and MWH designed the study. MJS and DGG recruited subjects and collected data. MJS, MWH, and DMC performed data analysis. MJS and MWH drafted the article, with substantial contributions to its revision from DGG and DMC. SAF performed additional statistical analyses and provided substantial contributions to the article revision. MWH takes responsibility for the paper as a whole. Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This study was funded in part by NICHD K12HD43372-03, NHLBI K08HL085525-01. Publication dates: Available online August 30, 2007. Reprints not available from the authors. |
Vol 50 - N° 5
P. 601-607 - novembre 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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