Analysis of TGF-β1 gene polymorphisms in Hong Kong Chinese patients with asthma - 15/08/11
, Helen C.M. Leung, MPhil a, Siu P. Ho, BSc a, Barbara K.W. Law, BSc a, Alice S.S. Ho, MBChB b, Wah K. Lam, MD a, Mary S.M. Ip, MD a, Moira M.W. Chan-Yeung, MB a
Reprint requests: Judith C. W. Mak, PhD, Department of Medicine, Room 804, Administration Block, Queen Mary Hospital, Hong Kong SAR, China.Hong Kong SAR, China
Abstract |
Background |
The C-509T polymorphism of TGF-β1 gene has been associated with asthma and atopy in white populations.
Objective |
We investigated the association between asthma and previously identified polymorphisms at C-509T and T869C of the TGF-β1 gene among 250 Chinese patients with asthma and 308 healthy controls in Hong Kong.
Methods |
Genotyping was performed on peripheral blood genomic DNA by using PCR-RFLP.
Results |
There were no differences in the frequencies of genotypes and alleles between patients and controls. The C-509T and T869C polymorphisms were in tight linkage disequilibrium (P < .01). Among atopic subjects, significant differences were found in genotype and allele frequencies for T869C polymorphism between patients and controls (P = .014 and P = .019, respectively), and individuals bearing the CC genotype were associated with increased risk for the development of asthma (odds ratio, 2.58; 95% CI, 1.17-5.66; P = .018) after adjusting for age, sex, and smoking status. Individuals with asthma bearing the CT genotype of the C-509T polymorphism had significantly increased risk for severe airflow obstruction compared with individuals who had mild obstruction (odds ratio, 4.00; 95% CI, 1.06-15.08; P = .035).
Conclusion |
Our results indicate that the polymorphisms at C-509T and T869C of the TGF-β1 gene are associated with asthma susceptibility in atopic subjects of the Hong Kong Chinese population, and the C-509T polymorphism may play a role in the pathogenesis of airflow obstruction.
Le texte complet de cet article est disponible en PDF.Key words : Transforming growth factor-β1, polymorphism, asthma, disease severity, Hong Kong Chinese population
Abbreviation used : OR
Plan
| Supported by a grant from the Hong Kong Research Grant Council (HKU7223/01M). |
Vol 117 - N° 1
P. 92-96 - janvier 2006 Retour au numéro
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