Sirolimus-eluting stents compared with standard stents in the treatment of patients with primary angioplasty - 16/08/11
, Sara Ballesteros, PhD, Jaime Nevado, PhD, Mónica Fernández, PhD, Manuel Villa, PhD, Ángel Sánchez, MD, PhD, Gabriel Retegui, PhD, Dolores García, PhD, Ángel Martínez, MD, PhDRésumé |
Background |
Sirolimus-eluting stents have been shown to decrease restenosis and reintervention as compared with standard stents. We evaluated the use of sirolimus-eluting stents in primary percutaneous coronary intervention for acute myocardial infarction with ST-segment elevation.
Methods |
We randomly assigned 120 patients to compare sirolimus-eluting stents with uncoated stents in primary percutaneous coronary intervention for acute myocardial infarction with ST-segment elevation. The primary end point was composite: death from cardiac causes, recurrent myocardial infarction, or target-lesion revascularization after 360 days.
Results |
The rate of the primary end point was 6.7% in the sirolimus-eluting stent and 11% in the bare-metal stent group (relative risk 1.75, 95% CI 0.47-6.57, P = .402). The survival free from target-vessel failure showed a higher trend in the sirolimus-eluting stent group than in the bare-metal stent group (0.0% vs 5.7%, P = .064). There was no significant difference between the 2 groups in the rate of death (5% and 3.6%, respectively; P = .736), reinfarction (1.7% and 1.8%, respectively; P = .940), or stent thrombosis (3.4% and 1.8%, respectively; P = .621).
Conclusions |
Among selected patients with acute myocardial infarction and ST-segment elevation, the use of sirolimus-eluting stents shows a trend to reduce the rate of target-vessel revascularization in comparison with bare-metal stent.
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Vol 154 - N° 1
P. 164.e1-164.e6 - juillet 2007 Retour au numéro
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