Expression of c-jun oncogene in hyperplastic and carcinomatous human prostate - 16/08/11
, Dionisios Mitropoulos b, Aspasia Kyroudi-Voulgari a, Kiriaki Soura a, Christos Kittas a
Reprint requests: Dina G. Tiniakos, M.D., Ph.D., Laboratory of Histology and Embryology, National and Kapodistrian University of Athens Medical School, 75, M. Asias Street, Goudi, Athens 11527, GreeceAbstract |
Objectives |
To investigate c-jun oncoprotein (JUN) expression in diseases of the human prostate gland at the tissue level and to determine its relationship to clinicopathologic variables.
Methods |
The expression of JUN was studied using immunohistochemistry in archival tissue from benign prostatic hyperplasia (BPH) (n = 16) and prostate adenocarcinoma (PCa) (n = 36) specimens.
Results |
JUN-specific positive nuclear immunostaining was observed in 13 (81.25%) of 16 BPH and 31 (86.1%) of 36 PCa specimens. JUN-specific immunostaining was significantly stronger in the PCa than in the BPH tissue (P = 0.006). In the PCa tissue, no significant correlation was found between JUN immunohistochemical expression and tumor histologic grade (Gleason score) or serum prostate-specific antigen level.
Conclusions |
JUN expression may play a role in normal cell function of the prostatic epithelium and is expressed in most BPH and PCa samples. The finding that JUN-specific immunostaining intensity was stronger in the vast majority of PCa than in the BPH samples implies that the role of c-jun may be enhanced during malignant transformation.
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Vol 67 - N° 1
P. 204-208 - janvier 2006 Retour au numéro
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