The Tei Index Identifies a Differential Effect on Left and Right Ventricular Function with Low-dose Anthracycline Chemotherapy - 16/08/11
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, Anton Kruger, MB † : FRCP, FRCPath, Colin Pritchard, BA, BPhil, MA, MSc, PhD § Department of Cardiology, Royal Cornwall Hospital, Cornwall, United Kingdom Reprint requests: Mark Belham, MD, MRCP, MB, ChB, Department of Cardiology, Royal Cornwall Hospital, Truro, Cornwall, United Kingdom.Résumé |
Objective |
We sought to study the relative effect on left ventricular (LV) and right ventricular (RV) function of low-dose anthracycline-containing chemotherapy regimes.
Methods |
A total of 23 patients (mean age 48 ± 20 years) underwent echocardiographic examinations before any anthracycline had been administered and then after low-dose anthracycline (doxorubicin 50-125 mg/m2). The Tei index was used to compare the relative effects on RV and LV function.
Results |
Anthracycline administration was significantly associated with an increase in the LV Tei index (0.38 ± 0.12 vs 0.46 ± 0.16, P = .02). There was no significant change in the RV Tei index (0.19 ± 0.10 vs 0.20 ± 0.10, P = .72). Comparing the relative effect on global LV and RV function the change in LV Tei was significantly greater than the change in RV Tei (0.07 ± 0.13 vs 0.01 ± 0.09, P = .044).
Conclusions |
Low-dose anthracycline administration has a significant negative impact on LV function but does not affect RV function.
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Vol 19 - N° 2
P. 206-210 - février 2006 Retour au numéro
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