Molecular Control of Liver Development - 17/08/11
Doi : 10.1016/j.cld.2005.10.002
Valérie A. McLin, MD a, ⁎ 
, Aaron M. Zorn, PhD b
, Aaron M. Zorn, PhD b a Baylor College of Medicine, Texas Childrens' Liver Center, 1102 Bates Street, Houston, TX 77006, USA
b Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati OH 45229, USA
⁎Corresponding author
Résumé |
Recent studies using animal models have elucidated a growing number of evolutionarily conserved genes and pathways that control liver development from the embryonic endoderm. It is increasingly clear that the genetic programs active in embryogenesis are often deregulated or reactivated in disease, cancer, and tissue repair. Understanding the molecular control of liver development should impact diagnosis and treatment of pediatric and adult liver diseases and aid in efforts to differentiate liver tissue in vitro for stem cell–based therapies.
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| This work has been supported by National Institutes of Health grants F32HD047121-01 (VAM) and R01HD04572-01 (AMZ). |
© 2006
Elsevier Inc. Tous droits réservés.
Vol 10 - N° 1
P. 1-25 - février 2006 Retour au numéro
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