Hypermagnesemia does not increase brain intracellular magnesium in newborn swine - 17/08/11
, Ronald J.T Corbett, MD †, Jeffrey M Perlman, MD ‡, Abbot R Laptook, MD ⁎, ‡ Texas Women’s Hospital, Houston, Texas, USA Communications should be addressed to: Dr. Laptook; Department of Pediatrics; University of Texas Southwestern Medical Center at Dallas; 5323 Harry Hines Boulevard; Dallas, TX 75390-9063Abstract |
Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 ± 0.04 mM) and 40-day groups (0.21 ± 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated.
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Vol 25 - N° 4
P. 304-308 - octobre 2001 Retour au numéro
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