Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome - 17/08/11
Doi : 10.1016/S0887-8994(01)00296-X
Susan J. Hayflick, MD 
, †, ‡, ⁎, Johann M. Penzien, MD §, Wolfgang Michl, MD ¶, Uzma M. Sharif, MD 
, N.Paul Rosman, MD , #AFF7, Patricia G. Wheeler, MD
, †, ‡, ⁎, Johann M. Penzien, MD §, Wolfgang Michl, MD ¶, Uzma M. Sharif, MD , N.Paul Rosman, MD , #AFF7, Patricia G. Wheeler, MD a Department of Molecular and Medical Genetics; Oregon Health Sciences University; Portland, OR, USA
b Department of Pediatrics; Oregon Health Sciences University; Portland, OR, USA
c Department of Neurology; Oregon Health Sciences University; Portland, OR, USA
d Division of Neuropediatrics; Zentralklinikum; Augsburg, Germany
e Division of Pediatric Radiology; Zentralklinikum; Augsburg, Germany
f Department of Neurology; Tufts University School of Medicine; New England Medical Center; Boston, Massachusetts, USA
g Department of Pediatrics; Tufts University School of Medicine; New England Medical Center; Boston, Massachusetts, USA
*Communications should be addressed to: Dr. Hayflick; Oregon Health and Science University; Mail Code L103a; 3181 SW Sam Jackson Park Rd.; Portland, OR 97201
Abstract |
Two families are presented in which siblings of children affected with Hallervorden-Spatz syndrome exhibited characteristic cranial magnetic resonance imaging changes before developing clinical features of the disease. Linkage to a major locus on chromosome 20p supported the diagnosis of Hallervorden-Spatz syndrome. In some patients with Hallervorden-Spatz syndrome, iron is radiographically evident before the onset of clinical symptoms.
Le texte complet de cet article est disponible en PDF.Plan
© 2001
Elsevier Science Inc. Tous droits réservés.
Vol 25 - N° 2
P. 166-169 - août 2001 Retour au numéro
Article précédent
- Julius Hallervorden’s wartime activities: Implications for science under dictatorship
- Michael I Shevell, Jüergen Peiffer
- Striatal and pontocerebellar hypoperfusion in Hallervorden-Spatz syndrome
- Pierre Castelnau, Monica Zilbovicius, Maria-Joao Ribeiro, Lucie Hertz-Pannier, Helene Ogier, Philippe Evrard
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?