Effects of exercise training on 5 inflammatory markers associated with cardiovascular risk - 17/08/11
Résumé |
Background |
Cross-sectional studies suggest that regular exercise has anti-inflammatory effects, leading to lower levels of several proatherogenic inflammatory markers. However, this has yet to be confirmed by randomized prospective trials. We performed a randomized controlled trial to assess whether exercise training decreases levels of 5 inflammatory markers linked to future cardiovascular risk: white blood cell count, fibrinogen, C-reactive protein, soluble intercellular adhesion molecule 1, and soluble CD40 ligand.
Methods |
One hundred fifty-two healthy female smokers were randomized to either 12 weeks of exercise training or health education as part of a smoking cessation program. Smoking was held steady for the first 6 weeks, and thereafter, smoking cessation was actively attempted. One hundred four participants completed 6 weeks, and 88 completed 12 weeks. Fitness and circulating inflammatory marker levels were measured at baseline, 6 weeks, and 12 weeks. To avoid potential confounding from changes in smoking exposure during the second 6 weeks of the trial, the primary end point was change in inflammatory marker levels from baseline to 6 weeks. Change in inflammatory markers from baseline to 12 weeks was a secondary end point.
Results |
At baseline, greater physical fitness was associated with lower white blood cell, fibrinogen, and C-reactive protein levels, but these associations were not statistically significant after adjusting for body mass index (P > .1 for all). Fitness improved significantly in the exercise group at both 6 and 12 weeks. However, there were no differences in levels of any inflammatory marker between the exercise and control groups at either 6 weeks (primary end point) or 12 weeks (secondary end point) (P > .05 for all comparisons).
Conclusion |
In female smokers, baseline associations between fitness and inflammatory markers were largely attributable to differences in body fat; regular exercise did not reduce levels of any of the inflammatory markers studied despite a significant improvement in fitness at both 6 and 12 weeks.
Le texte complet de cet article est disponible en PDF.Plan
| This work was supported by project grant 81410 from the Auckland Medical Research Foundation, project grant 943 from the National Heart Foundation of New Zealand, and by the loan of a CRP autoanalyzer by Dade Behring (NZ) Ltd. Dr Hammett was the recipient of a Cardiac Society of Australia and New Zealand/Merck Sharp and Dohme Fellowship. The authors gratefully acknowledge Kendra McFarlane and Dean Fourie for supervision of exercise training and data collection, Pauline O'Brien and Loretta Bush for assistance with blood collection, Roy The for CRP analysis, and Charlene Nell for secretarial assistance. |
Vol 151 - N° 2
P. 367.e7-367.e16 - février 2006 Retour au numéro
Article précédent
- Type D personality and diabetes predict the onset of depressive symptoms in patients after percutaneous coronary intervention
- Susanne S. Pedersen, Andrew T.L. Ong, Karel Sonnenschein, Patrick W. Serruys, Ruud A.M. Erdman, Ron T. van Domburg
- Alcohol consumption, atherosclerotic progression, and prognosis among patients with coronary artery bypass grafts
- Kenneth J. Mukamal, Saket Girotra, Murray A. Mittleman
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?