Nimesulide Oral Administration Increases the Intraocular pressure-lowering Effect of Latanoprost in Patients With Primary Open-angle Glaucoma - 18/08/11
, Antonio Caccavale, MD b, Adolfo Sebastiani, MD a
Inquiries to Francesco Parmeggiani, MD, PhD, Sezione di Clinica Oculistica, Dipartimento di Discipline Medico-Chirurgiche della Comunicazione e del Comportamento, Università degli Studi di Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy; Fax: (+39) 532-210424Résumé |
Purpose |
To verify the short-term influence of an orally administered nonsteroidal anti-inflammatory drug on the intraocular pressure (IOP) of primary open-angle glaucoma patients in therapy with a topical prostaglandin analog.
Design |
Randomized cross-over double-blind study.
Methods |
Sixteen adults with primary open-angle glaucoma, receiving 0.005% latanoprost eyedrops once daily, were treated with a single dose of either 100 mg nimesulide or placebo. IOP was recorded at baseline and at 1, 2, 4, 8, 12, and 24 hours.
Results |
After nimesulide administration, there was a decrease in IOP (with a fall at the second hour, P < .01) that remained significant 8 hours later (P < .05). At 12 and 24 hours, there were unremarkable IOP differences between the two regimens.
Conclusions |
In patients with primary open-angle glaucoma, single-dose nimesulide significantly enhances the latanoprost-induced IOP-lowering effects during the short plasma half-life of this non-steroidal anti-inflammatory drug.
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Vol 141 - N° 2
P. 379-381 - février 2006 Retour au numéro
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