Delayed onset bleomycin-induced pneumonitis - 18/08/11
, B. Uzel b, K. Kaynak c, O. Demirhan c, C. Akman d, F. Oz e, M. Yaman a
Address for correspondence: Mustafa Ozguroglu, M.D., Çiçekçi Bostan sok., Mesa koru evleri, C1/1 Altunizade, Istanbul, TurkeyAbstract |
We describe a 39-year-old male patient who developed bleomycin-induced pneumonitis 2 years after completion of chemotherapy for nonseminomatous testicular cancer. Bleomycin sometimes causes fatal pulmonary toxicity, including bleomycin-induced pneumonitis. The central event in the development of pneumonitis is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals. Pulmonary toxicity usually begins at bleomycin administration. The development of bleomycin-induced pneumonitis up to 6 months after bleomycin therapy has also been reported. We report a patient who developed bleomycin-induced pneumonitis 2 years after the initiation of bleomycin-containing chemotherapy regimens.
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Vol 66 - N° 1
P. 195 - juillet 2005 Retour au numéro
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