Associations between fetal inherited thrombophilia and adverse pregnancy outcomes - 18/08/11
, Alastair H. MacLennan, MD a, Nard G. Janssen c, Willem J. Kist c, William M. Hague, MD a, Eric A. Haan, MBBS d, f, Paul N. Goldwater, MBBS b, f, Kevin Priest, BSc e, Gustaaf A. Dekker, PhD afor the South Australian Cerebral Palsy Research Group
Reprint requests: Dr Catherine S. Gibson, The University of Adelaide Department of Obstetrics and Gynaecology, Women’s and Children’s Hospital, 1st Floor Queen Victoria Building, 72 King William Road, North Adelaide 5006, Adelaide, South Australia.Abstract |
Objective |
The purpose of this study was to investigate associations between fetal inherited thrombophilia and adverse pregnancy outcomes, including pregnancy-induced hypertensive disorders (PIHD), antepartum hemorrhage (APH), small-for-gestational age <10th percentile (SGA), and preterm birth (PTB).
Study design |
Seven hundred and seventeen cases and 609 controls were genotyped for Factor V Leiden (FVL, G1691A), Prothrombin gene mutation (PGM, G20210A), and Methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C using DNA from newborn screening cards.
Results |
For babies born <28 weeks’ gestation, PGM was associated with an increased risk of SGA (OR 6.40, 95%CI 1.66-24.71) and APH with SGA (OR 6.35, 95%CI 1.63-24.75). Homozygous MTHFR A1298C was associated with an increased risk of SGA for babies born 28-31 weeks gestation (OR 4.00, 95%CI 1.04-15.37), and with APH and SGA for babies born <32 weeks’ gestation (OR 3.57, 95%CI 1.09-11.66). Homozygous MTHFR C677T was associated with a reduced risk of PTB and SGA (OR 0.52, 95%CI 0.28-0.96) for babies born 32 to 36 weeks’ gestation. Homozygous FVL decreased the risk of PTB <32 weeks’ gestation (OR 0.55, 95%CI 0.31-0.98).
Conclusion |
Fetal thrombophilic polymorphisms may be related to adverse pregnancy outcomes, in particular SGA.
Le texte complet de cet article est disponible en PDF.Key words : Fetal thrombophilia, Polymorphisms, Adverse pregnancy outcomes
Plan
| Supported by The Australian National Health and Medical Research Council, The Channel 7 Children’s Research Foundation, The University of Adelaide, and The South Australian Government Captive Insurance Corporation. The supporting sources had no influence on the analysis, writing, or submission of the manuscript. Presented at the 26th Annual Meeting of the Society for Maternal Fetal Medicine, Miami, FL, January 30-February 4, 2006. Supplementary material available at: www.ajog.org. |
Vol 194 - N° 4
P. 947.e1-947.e10 - avril 2006 Retour au numéro
Article précédent
- Editorial
- Jay D. Iams
- Antepartum vaginal bleeding, fetal exposure to oral pathogens, and risk for preterm birth at <35 weeks of gestation
- Kim A. Boggess, Kevin Moss, Amy Murtha, Steven Offenbacher, James D. Beck
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?