The Hygiene Hypothesis Revisited - 18/08/11
Doi : 10.1016/j.iac.2005.03.005
Jeremy D. Bufford, MD ⁎, James E. Gern, MD 
Department of Pediatrics, University of Wisconsin-Madison, K4/910 CSC, 600 Highland Avenue, Madison, WI 53792–9988, USA
*Corresponding author
Résumé |
The original hygiene hypothesis proposed that reductions in family size and exposure to childhood infections were responsible for the rise in atopic diseases. Numerous epidemiologic and longitudinal studies have been performed to test this hypothesis, which has evolved in response to these findings and emerging concepts related to the innate immune response and immunoregulatory mechanisms. Collectively, these advances raise hope that the concepts espoused in original hygiene hypothesis may soon lead to new preventive approaches to atopic diseases.
Le texte complet de cet article est disponible en PDF.Plan
| Supported by NIH grants R01HL61879-01, P01HL70831-01, and 5M01 RR03186-18. |
© 2005
Elsevier Inc. Tous droits réservés.
Vol 25 - N° 2
P. 247-262 - mai 2005 Retour au numéro
Article précédent
- The Atopic March: The Pattern of Allergic Disease Development in Childhood
- Eugenia L. Hahn, Leonard B. Bacharier
- Allergic Rhinoconjunctivitis: Epidemiology
- Wanda Phipatanakul
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?