Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett's esophagus - 18/08/11
Reprint requests: Jacques Bergman, MD, PhD, Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.Amsterdam, the Netherlands
Abstract |
Background |
The aim of this study was to investigate the feasibility of detecting high-grade dysplasia (HGD) and early cancer (EC) in Barrett's esophagus (BE) with a prototype video autofluorescence endoscope.
Methods |
Sixty patients with BE were evaluated with a prototype, high-resolution videoendoscope that has separate charge-coupled devices for white light endoscopy (WLE) and autofluorescence imaging (AFI). Nondysplastic BE appears green on AFI, whereas potentially neoplastic areas appear blue/violet. The BE was first screened with WLE for visible abnormalities and then was examined by AFI to detect additional lesions. Lesions that raised a suspicion of neoplasia and control areas that were normal on AFI were sampled for histopathologic assessment. Finally, random 4-quadrant biopsy specimens were obtained at 2-cm intervals.
Results |
A diagnosis of HGD/EC was made in 22 patients; one patient had no visible abnormality, and 21 had endoscopically detectable areas with HGD/EC. In 6 of the latter 21 patients, the HGD/EC was detected with AFI alone; in another patient, HGD/EC was detected with AFI and random biopsies. In 14 patients, HGD/EC was detected with both WLE and AFI; in 3 of these 14 patients, additional lesions containing HGD/EC were detected by AFI alone.
Conclusions |
The results of this study suggest that video AFI may improve the detection of HGD/EC in patients with BE.
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| See CME section; p. 729. This study was partly presented at the annual meeting of the American Gastroenterology Association, May 15-20, 2004, New Orleans, Louisiana (Gastroenterology 2004;126:A51). |
Vol 61 - N° 6
P. 679-685 - mai 2005 Retour au numéro
Article précédent
- A randomized crossover study comparing light-induced fluorescence endoscopy with standard videoendoscopy for the detection of early neoplasia in Barrett's esophagus
- Mohammed A. Kara, Marianne E. Smits, Wilda D. Rosmolen, Albert C. Bultje, Fiebo J.W. ten Kate, Paul Fockens, Guido N.J. Tytgat, Jacques J.G.H.M. Bergman
- Autofluorescence imaging: have we finally seen the light?
- Thomas D. Wang, George Triadafilopoulos
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