Factors that regulate naturally occurring T regulatory cell–mediated suppression - 18/08/11
Reprint requests: Donald Y. M. Leung, MD, PhD, National Jewish Medical Research Center, 1400 Jackson St, Room K926i, Denver, CO 80206.Denver, Colo, and Taoyuan, Taiwan
Abstract |
T regulatory (Treg) cells play a key role in the modulation of allergic and autoimmune responses. This review will discuss the factors that regulate naturally occurring Treg (nTreg) cell–mediated suppression. The involvement of cytokines, costimulatory molecules, and ligands on antigen-presenting cells in the inhibition of nTreg cell–mediated suppression in vitro is summarized. Understanding the events that control suppressive function of nTreg cells will allow manipulation of these cells to inhibit or enhance their functions in the development of novel therapies for autoimmune and allergic diseases.
Le texte complet de cet article est disponible en PDF.Key words : T regulatory cells, immune suppression, superantigens, atopic dermatitis
Abbreviations used : APC, CTLA-4, GITR, GITR-L, HTLV-1, IPEX, NFAT, NF-κB, nTreg cell, TLR, Treg cell
Plan
| Supported in part by the National Institutes of Health (NIH) National Research Service Award (T32 AI 07365) and the American Academy of Allergy, Asthma, and Immunology Fujisawa Skin Diseases Award (M.D.H.); the Centers for Disease Control and Prevention (J.F.J.); NIH grants AI052453 and AR45676 and a VA Merit Award (R.L.G.); NIH grants AR41256 and 5R21AR051634, NIH/National Institute of Allergy and Infectious Disease contracts N01 AI40029 and N01 AI40030, General Clinical Research Center grant MO1 RR00051 from the Division of Research Resources, the Edelstein Family Chair in Pediatric Allergy and Immunology, and the University of Colorado Cancer Center (D.Y.M.L.). |
Vol 116 - N° 5
P. 1094-1100 - novembre 2005 Retour au numéro
Article précédent
- The natural history of tree nut allergy
- David M. Fleischer, Mary Kay Conover-Walker, Elizabeth C. Matsui, Robert A. Wood
- Sporadic case of warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis syndrome
- Michael D. Tarzi, Michael Jenner, Keith Hattotuwa, Asma Z. Faruqi, George A. Diaz, Hilary J. Longhurst
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?