Successful Tear Lipid Layer Treatment for Refractory Dry Eye in Office Workers by Low-Dose Lipid Application on the Full-Length Eyelid Margin - 18/08/11
, Murat Dogru, MD b, d, Kazumi Fukagawa, MD b, c, d, Miki Uchino, MD b, Yukihiro Matsumoto, MD b, d, Megumi Saiki, CO b, Kazuo Tsubota, MD b, d
Inquiries to Eiki Goto, MD, Department of Ophthalmology, School of Dental Medicine, Tsurumi University, 2–1-3 Tsurumi, Tsurumi-ku, Yokohama City, Kanagawa, Japan 230–8501Résumé |
Purpose |
To test tear lipid layer treatment by low-dose lipid application on the full-length eyelid margin for the treatment of office workers with dry eyes refractory to conventional treatments.
Design |
Prospective interventional case series.
Methods |
Thirty eyes of 30 office workers with dry eyes with dark tear interference images, which did not respond to conventional treatments, were included. To supply lipid using a commercially available nonpreserved topical medication having both polar and nonpolar lipid base, ofloxacin eye ointment (Santen Pharmaceutical, Osaka, Japan) was selected. Low-dose ofloxacin ointment application on the full-length eyelid margin was carried out three times a day for two weeks. The symptom of ocular dryness using a visual analog scale, tear interferometry to assess lipid layer thickness (LLT), corneal fluorescein staining, tear-film breakup time (BUT), and meibum expressibility gradings were compared.
Results |
After the treatment, the symptom score of ocular dryness decreased from 91.4 ± 11.9 to 33.6 ± 21.0 (P < .0001), LLT increased from 39 ± 4 nm to 161 ± 91 nm (P < .0001), BUT was prolonged from 2.6 ± 1.6 seconds to 4.8 ± 2.1 seconds (P = .01), and meibum expressibility gradings decreased from 2.8 ± 1.3 to 1.6 ± 1.3 (P = .0005).
Conclusion |
For office workers with refractory dry eyes, tear lipid layer treatment by low-dose ointment applied on the full-length eyelid margin was shown to be an effective approach. The applied lipid formed a uniform lipid layer, which contributed to tear stability, leading to the improvement of the symptom.
Le texte complet de cet article est disponible en PDF.Plan
| This study was supported by grant 17791254 from the Japanese Ministry of Education, Culture, Sports, Science, and Technology, Tokyo, Japan. |
Vol 142 - N° 2
P. 264 - août 2006 Retour au numéro
Article précédent
- Injection of Cultured Autologous Fibroblasts Into the Subconjunctival Space of Rabbits Treated With Mitomycin C
- Jeong-Min Hwang, Changwon Kee
- Use of Topical Human Amniotic Fluid in the Treatment of Acute Ocular Alkali Injuries in Mice
- Samantha Herretes, Olan Suwan-Apichon, Ashkan Pirouzmanesh, Johann M.G. Reyes, Aimee T. Broman, Marisol Cano, Peter L. Gehlbach, Edith D. Gurewitsch, Elia J. Duh, Ashley Behrens
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?