Maternal gestational protein-calorie restriction decreases the number of glomeruli and causes glomerular hypertrophy in adult hypertensive rats - 18/08/11
Reprint requests: Carlos A. Mandarim-de-Lacerda, MD, PhD, Universidade do Estado do Rio de Janeiro, Centro Biomédico, Instituto de Biologia, Laboratório de Morfometria e Morfologia Cardiovascular, Av 28 de Setembro 87 (fds) – 20551-030 Rio de Janeiro, RJ, Brazil.Abstract |
Objective |
This work analyzed the renal function and structure in offspring rats that were submitted to maternal protein-calorie restriction during prenatal or lactation periods.
Study design |
Kidneys from adult offspring were studied. Animals from mothers that were submitted to food restriction were separated in 3 groups: control, prenatal restriction, and lactation restriction. Blood pressure, microalbuminuria, and glomerular filtration rate were determined. Kidney cortical remodeling was analyzed with stereology; volume-weighted glomerular volume and the number of glomeruli were estimated.
Results |
Adult prenatal restriction offspring showed enhanced microalbuminuria, decreased glomerular filtration rate, and hypertension; their kidneys showed a smaller number of hypertrophied glomeruli than control and lactation restriction animals.
Conclusion |
Maternal prenatal protein-calorie restriction in rats causes kidney disease in adult offspring, which is characterized by hypertension and renal dysfunction and suggests secondary kidney remodeling because of an impairment of glomerulogenesis.
Le texte complet de cet article est disponible en PDF.Key words : Malnutrition, Nephrogenesis, Hypertension, Stereology
Plan
| Supported by the Brazilian National Council for Scientific and Technological Development and The Rio de Janeiro State Foundation for Research. |
Vol 192 - N° 3
P. 945-951 - mars 2005 Retour au numéro
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