Extracellular matrix changes in the umbilical arteries of growth-restricted fetuses - 18/08/11
Abstract |
Objective |
This study was undertaken to determine whether the expression of extracellular matrix components (ECM) is altered in the umbilical arteries from preterm fetal growth-restricted (FGR) pregnancies.
Study design |
Preterm pregnancies with FGR were compared with appropriately grown preterm pregnancies. Umbilical artery messenger RNA (mRNA) levels for fibrillar collagens I and III, nonfibrillar collagen XIV, and decorin were determined by using relative reverse transcriptase polymerase chain reaction (RT-PCR). The mRNA expression was compared between cases and controls by using the Student t test. P ≤ .05 was considered significant.
Results |
Eight FGR cases and 5 control pregnancies were analyzed. Mean counts per minute (cpm) ± SEM for collagen I and collagen III were increased in FGR pregnancies. There were no differences in mRNA expression of collagen XIV or decorin.
Conclusion |
Increased mRNA expression of collagen I and III, but not collagen XIV or decorin, is found in the umbilical arteries of preterm FGR pregnancies.
Le texte complet de cet article est disponible en PDF.Key words : Fetal growth restriction, Extracellular matrix remodeling, Fetal origins of adult disease
Plan
| Supported by NIH grant EY09056 (M.K.G.), center grant ES05022, UMDNJ Foundation grant 502759, and Samuel A. Pasquale research grant 505897. Oral presentation at the 25th Annual Meeting of the Society for Maternal-Fetal Medicine, February 7-12, 2005, Reno, Nev. Reprints not available from the authors. |
Vol 192 - N° 4
P. 1053-1059 - avril 2005 Retour au numéro
Article précédent
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