Inflammation increases vulnerability to hypoxia in newborn piglets: Effect of reoxygenation with 21% and 100% O2 - 18/08/11
, Marjolein Braakhuis a, J. Frederik Frøen, MD, PhD a, b, Babill Stray-Pedersen, MD, PhD b, Ola Didrik Saugstad, MD, PhD a
Reprint requests: Kristin Lyng, Department of Pediatric Research, Rikshospitalet University Hospital, 0027 Oslo, Norway.Abstract |
Objective |
The purpose of this study was to assess whether inflammation increases vulnerability to hypoxia, and influences the effect of 100% O2 and 21% O2 reoxygenation on brain.
Study design |
Newborn piglets (n=31) were randomized to 4 interventional groups: pretreatment with saline or endotoxin. After hypoxia they were reoxygenated with 21% or 100% oxygen for 30 minutes, followed by 21% oxygen for all groups. To assess brain injury we measured extracellular brain tissue glucose, glycerol, and lactate/pyruvate by microdialysis, brain tissue oxygen tension, and laser Doppler flow.
Results |
Administration of endotoxin reduced the time to reach base excess (BE) −20 mmol/L by median 32 minutes compared with saline (P < .05). We found no differences in changes in biochemical markers, brain tissue microcirculation, or oxygen tension between piglets in the 4 groups.
Conclusion |
Endotoxin and hypoxia acted synergistically in inducing metabolic acidosis. In the presence of experimental inflammation, 21% oxygen seems as effective as 100% O2 in reoxygenating piglets.
Le texte complet de cet article est disponible en PDF.Key words : Cerebral metabolism, Hypoxia, Intrauterine inflammation, Pigs, Resuscitation, Oxygen treatment
Plan
Vol 192 - N° 4
P. 1172-1178 - avril 2005 Retour au numéro
Article précédent
- No increase in rates of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus in the era of intrapartum antibiotic prophylaxis
- Katherine T. Chen, Karen M. Puopolo, Eric C. Eichenwald, Andrew B. Onderdonk, Ellice Lieberman
- Experimental intrauterine Ureaplasma infection in sheep
- Timothy J.M. Moss, Ilias Nitsos, Machiko Ikegami, Alan H. Jobe, John P. Newnham
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?