Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction - 18/08/11
, Ramón Rodrigo, MSc b, Pilar Barja b, Cleofina Bosco b, Virginia Fernández, PhD b, Hernán Muñoz, MD a, Emiliano Soto-Chacón, MD a
Reprint requests: Mauro Parra, MD, Unidad Medicina Fetal, Hospital Clínico Universidad de Chile, Santos Dumont 999, Independencia, Santiago, Chile.Abstract |
Objective |
This study was undertaken to evaluate whether screening through a uterine artery (UtA) Doppler and biochemical markers of oxidative stress and endothelial dysfunction predict preeclampsia.
Study design |
UtA Doppler was performed at 11 to 14 and 22 to 25 weeks on 1447 asymptomatic pregnant women. Oxidative stress, endothelial dysfunction, and antiangiogenic state were assessed in women who later developed preeclampsia and normotensive controls.
Results |
There was a significantly increased of UtA pulsatility index (PI), plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), PAI-1/PAI-2 ratio, and F-2 isoprostane in women who subsequently developed preeclampsia compared with control pregnancies. Multivariate logistic regression showed that increased UtA PI performed at 23 weeks was the best predictor for preeclampsia.
Conclusion |
This study demonstrates early changes in markers of impaired placentation, antiangiogenic state, oxidative stress, and endothelial dysfunction suggesting that these derangements may play a role in the pathogenesis of preeclampsia. Our data point to UtA as the best test to predict preeclampsia at 23 weeks of gestation.
Le texte complet de cet article est disponible en PDF.Key words : Preeclampsia, Doppler, Screening, Biochemical markers
Plan
| Supported by the Fondo Nacional de Ciencia y Tecnología (FONDECYT), grant number 1020080. |
Vol 193 - N° 4
P. 1486-1491 - octobre 2005 Retour au numéro
Article précédent
- Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy
- Alice R. Goepfert, Michael Varner, Kenneth Ward, Cora Macpherson, Mark Klebanoff, Robert L. Goldenberg, Brian Mercer, Paul Meis, Jay Iams, Atef Moawad, J. Chris Carey, Kenneth Leveno, Ronald Wapner, Steve N. Caritis, Menachem Miodovnik, Yoram Sorokin, Mary J. O'Sullivan, J. Peter Van Dorsten, Oded Langer, for the NICHD Maternal-Fetal Medicine Units Network
- Pregnancy interruption after second trimester diagnosis of fetal structural anomalies: The New Jersey Fetal Abnormalities Registry
- Eden R. Rauch, John C. Smulian, Kristin DePrince, Cande V. Ananth, Stephen W. Marcella, for the New Jersey Fetal Abnormalities Registry
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?