Association Between Microarray Gene Expression Signature and Extravascular Matrix Patterns in Primary Uveal Melanomas - 18/08/11
Inquiries to J. William Harbour, MD, Box 8069, 660 S. Euclid, Avenue, Washington University School of Medicine, St. Louis, MO 63110; fax: (314) 747-5073Résumé |
Purpose |
To determine whether there is an association between gene expression profile and looping extravascular matrix patterns in primary uveal melanomas.
Design |
Laboratory investigation.
Methods |
Formalin-fixed, paraffin-embedded sections from 22 primary uveal melanomas that previously were analyzed by microarray gene expression profiling were stained for periodic acid-Schiff and scored in a masked fashion for the presence of looping extravascular matrix patterns.
Results |
A strong association was observed between looping patterns and the unfavorable class 2 molecular prognostic signature (P < .001).
Conclusions |
Looping extravascular matrix patterns occur almost exclusively in class 2 uveal melanomas. This finding may provide new insights into the pathogenesis and management of uveal melanoma.
Le texte complet de cet article est disponible en PDF.| This work was supported by National Eye Institute grants EY 13169 (J.W.H.) and EY 10457 (R.F), a Physician Scientist Award from Research to Prevent Blindness, Inc (J.W.H.), a grant from the Macula Society (J.W.H.), core grant EY 02687 and an unrestricted grant from Research to Prevent Blindness, Inc. (Department of Ophthalmology and Visual Sciences, Washington University School of Medicine). Dr. Lin is the AOS-Knapp Fellow in Ophthalmic Pathology. These sources of funding were used in the design and conduct of the study; and collection, management, analysis, and interpretation of the data. |
Vol 140 - N° 4
P. 748-749 - octobre 2005 Retour au numéro
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