Bilateral Diffuse Uveal Melanocytic Proliferation in a Patient With Cancer-Associated Retinopathy - 18/08/11
, Satoru Kase, MD a, Kazuhiko Yoshida, MD a, Hiroshi Ohguro, MD b, Masahiko Yokoi, MD a, Hiroyuki Iwaki, MD c, Shigeaki Ohno, MD a
Inquiries to Wataru Saito, MD, Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Nishi 7 chome, Kita 15 jou, Kita-ku, Sapporo 060-8638, Japan; fax: +81-11-736-0952Résumé |
Purpose |
To describe a patient with bilateral diffuse uveal melanocytic proliferation (BDUMP) and cancer-associated retinopathy (CAR).
Design |
Interventional case report.
Methods |
A 66-year-old woman developed progressive vision loss 4 months after total hysterectomy. Ophthalmologic examination, Western blot test of sera and aqueous humor, and immunohistochemistry of carcinoma cells were performed.
Results |
Testing revealed BDUMP and severe retinal dysfunction. Autoantibodies against recoverin and heat shock cognate protein 70 (hsc 70) were detected in serum. Cytoplasmic immunoreactivity for recoverin and hsc 70 was observed in endometrioid carcinoma cells.
Conclusions |
Simultaneous cases of BDUMP and CAR are rare. Aberrantly expressed recoverin and hsc 70 triggered serum autoantibody production, which caused photoreceptor degeneration.
Le texte complet de cet article est disponible en PDF.| Supported by a grant for Research on Sensory and Communicative Disorders from The Ministry of Health, Labor, and Welfare, and by Grants in aid for Scientific Research from The Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan. |
Vol 140 - N° 5
P. 942-945 - novembre 2005 Retour au numéro
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