Antivascular Endothelial Growth Factor Agents and Their Development: Therapeutic Implications in Ocular Diseases - 18/08/11
Inquiries to Peter K. Kaiser, MD, 9500 Euclid Ave, i-32, Cleveland, OH 44195Résumé |
Purpose |
To provide an overview of angiogenesis and vascular endothelial growth factor (VEGF) and discusses the development approach, safety, and efficacy results of current and emerging anti-VEGF therapies for ocular diseases.
Design |
Analysis of literature and current clinical trials of antiangiogenic agents for age-related macular degeneration (AMD).
Methods |
Literature review.
Results |
There are several novel antiangiogenic molecules that target vascular endothelial growth factor and are being used in the management of AMD. Large scale, Phase III trials have shown promising results in improving vision in this devastating disease.
Conclusions |
Therapies that target VEGF have shown tremendous promise as treatments for AMD.
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| Supported by The Cole Eye Institute, the employer of Peter K. Kaiser, MD, has received research grant support from Alcon, Allergan, Eyetech Pharmaceuticals, Genentech, Regeneron, Novartis, QLT, and SIRNA Therapeutics. Genentech has provided financial support for editorial assistance in the preparation of this manuscript. Peter K. Kaiser, MD is a member of the Scientific Advisory Boards of Alcon, Allergan, Bausch & Lomb, Genentech, Regeneron, Novartis, QLT, and SIRNA Therapeutics; and a consultant for Alcon, Occulogix and Quark. |
Vol 142 - N° 4
P. 660 - octobre 2006 Retour au numéro
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