Lung Function and Risk for Heart Failure Among Older Adults: The Health ABC Study - 19/08/11
, Andreas P. Kalogeropoulos, MD a, Bruce M. Psaty, MD, PhD b, Nicolas Rodondi, MD, MAS c, Douglas C. Bauer, MD d, Abida B. Butler, MD e, Annemarie Koster, PhD f, Andrew L. Smith, MD a, Tamara B. Harris, MD, MS f, Anne B. Newman, MD, MPH g, Stephen B. Kritchevsky, PhD h, Javed Butler, MD, MPH a
Requests for reprints should be addressed to Vasiliki V. Georgiopoulou, MD, Division of Cardiology, Emory University Hospital, 1462 Clifton Road NE, Suite 535A, Atlanta GA 30322Abstract |
Background |
The impact of abnormal spirometric findings on risk for incident heart failure among older adults without clinically apparent lung disease is not well elucidated.
Methods |
We evaluated the association of baseline lung function with incident heart failure, defined as first hospitalization for heart failure, in 2125 participants of the community-based Health, Aging, and Body Composition (Health ABC) Study (age, 73.6±2.9 years; 50.5% men; 62.3% white; 37.7% black) without prevalent lung disease or heart failure. Abnormal lung function was defined either as forced vital capacity (FVC) or forced expiratory volume in 1st second (FEV1) to FVC ratio below lower limit of normal. Percent predicted FVC and FEV1 also were assessed as continuous variables.
Results |
During follow-up (median, 9.4 years), heart failure developed in 68 of 350 (19.4%) participants with abnormal baseline lung function, as compared with 172 of 1775 (9.7%) participants with normal lung function (hazard ratio [HR] 2.31; 95% confidence interval [CI], 1.74-3.07; P <.001). This increased risk persisted after adjusting for previously identified heart failure risk factors in the Health ABC Study, body mass index, incident coronary heart disease, and inflammatory markers (HR 1.83; 95% CI, 1.33-2.50; P <.001). Percent predicted (%) FVC and FEV1 had a linear association with heart failure risk (HR 1.21; 95% CI, 1.11-1.32 and 1.18; 95% CI, 1.10-1.26, per 10% lower %FVC and %FEV1, respectively; both P <.001 in fully adjusted models). Findings were consistent in sex and race subgroups and for heart failure with preserved or reduced ejection fraction.
Conclusions |
Abnormal spirometric findings in older adults without clinical lung disease are associated with increased heart failure risk.
Le texte complet de cet article est disponible en PDF.Keywords : Elderly, Epidemiology, Heart failure, Pulmonary function test
Plan
| Funding: This work was supported in part by the Intramural Research Program of the National Institute of Aging, National Institutes of Health, Bethesda MD (Grants N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106); and by PHS (Grant UL1 RR025008) from the Clinical and Translational Science Award program, National Institutes of Health, National Center for Research Resources. Dr. Kritchevsky is also supported by National Heart, Lung, and Blood Institute grant R01-HL-7-4104. This work was also partially funded through an Emory University Heart and Vascular Board grant entitled “Novel Risk Markers and Prognosis Determination in Heart Failure.” |
|
| Conflict of Interest: None declared. |
|
| Authorship: All authors had access to the data and provided substantial input for this manuscript. |
Vol 124 - N° 4
P. 334-341 - avril 2011 Retour au numéro
Article précédent
- The Effects of Sex on Out-of-Hospital Cardiac Arrest Outcomes
- Manabu Akahane, Toshio Ogawa, Soichi Koike, Seizan Tanabe, Hiromasa Horiguchi, Tatsuhiro Mizoguchi, Hideo Yasunaga, Tomoaki Imamura
- Repeated Hemoglobin A1C Ordering in the VA Health System
- Archana Laxmisan, Mary Vaughan-Sarrazin, Peter Cram
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?