Perinatal risk indicators for long-term neurological morbidity among preterm neonates - 19/08/11
, Aleid G. van Wassenaer, MD, PhD b, Paula van Dommelen, PhD d, Ben Willem J. Mol, MD, PhD a, Brent C. Opmeer, PhD cDutch POPS-19 Collaborative Study Group
Reprints: Margreet Teune, MD, Academic Medical Center, Department of Obstetrics & Gynaecology, Room H4-140, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsRésumé |
Objective |
Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age.
Study design |
Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap.
Results |
Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively).
Conclusion |
In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity.
Le texte complet de cet article est disponible en PDF.Key words : long-term neurologic morbidity, perinatal risk indicator, prediction model, premature
Plan
| The list of participants of the Dutch POPS-19 Collaborative Study Group is published in the Acknowledgments. |
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| The racing flag logo above indicates that this article was rushed to press for the benefit of the scientific community. |
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| Supported by Grant no. 80-82325-98-9010 from ZonMW, The Netherlands–Organization for Health Research and Development, The Hague, The Netherlands. |
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| Cite this article as: Teune MJ, van Wassenaer AG, van Dommelen P, et al. Perinatal risk indicators for long-term neurological morbidity among preterm neonates. Am J Obstet Gynecol 2011;204:396.e1-14. |
Vol 204 - N° 5
P. 396.e1-396.e14 - mai 2011 Retour au numéro
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