Inactivation of surrogate coronaviruses on hard surfaces by health care germicides - 19/08/11
, William A. Rutala, PhD c, David J. Weber, MD, MPH c, Mark D. Sobsey, PhD d
Address correspondence to Lisa M. Casanova, PhD, Institute of Public Health, Georgia State University, P.O. Box 3995, Atlanta, GA 30302.
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Abstract |
Background |
In the 2003 severe acute respiratory syndrome outbreak, finding viral nucleic acids on hospital surfaces suggested surfaces could play a role in spread in health care environments. Surface disinfection may interrupt transmission, but few data exist on the effectiveness of health care germicides against coronaviruses on surfaces.
Methods |
The efficacy of health care germicides against 2 surrogate coronaviruses, mouse hepatitis virus (MHV) and transmissible gastroenteritis virus (TGEV), was tested using the quantitative carrier method on stainless steel surfaces. Germicides were o-phenylphenol/p-tertiary amylphenol) (a phenolic), 70% ethanol, 1:100 sodium hypochlorite, ortho-phthalaldehyde (OPA), instant hand sanitizer (62% ethanol), and hand sanitizing spray (71% ethanol).
Results |
After 1-minute contact time, for TGEV, there was a log10 reduction factor of 3.2 for 70% ethanol, 2.0 for phenolic, 2.3 for OPA, 0.35 for 1:100 hypochlorite, 4.0 for 62% ethanol, and 3.5 for 71% ethanol. For MHV, log10 reduction factors were 3.9 for 70% ethanol, 1.3 for phenolic, 1.7 for OPA, 0.62 for 1:100 hypochlorite, 2.7 for 62% ethanol, and 2.0 for 71% ethanol.
Conclusion |
Only ethanol reduced infectivity of the 2 coronaviruses by >3-log10 after 1 minute. Germicides must be chosen carefully to ensure they are effective against viruses such as severe acute respiratory syndrome coronavirus.
Le texte complet de cet article est disponible en PDF.Key Words : Coronavirus, disinfection, surfaces, severe acute respiratory syndrome, SARS, environmental
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| Supported by the Centers for Disease Control and Prevention, Atlanta, GA. |
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| Conflicts of interest: None to report. |
Vol 39 - N° 5
P. 401-407 - juin 2011 Retour au numéro
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