The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder - 19/08/11
, Ismael D. Silva, PhD a, Manoel J. Girão, PhD a, Marair G. Sartori, PhD a, Rodrigo A. Castro, PhD a
Reprints: Andrea Moura Rodrigues Maciel da Fonseca, PhD, Avenida Professor Alfredo Balena 190 Santa Efigênia, Belo Horizonte, MG, BrazilRésumé |
Objective |
The purpose of this study was to verify the association between the Trp 64 Arg polymorphism and idiopathic overactive bladder (OAB) syndrome.
Study Design |
A case-control study was conducted with 218 women. The case group consisted of 49 patients with OAB symptoms; the control group included 169 women without urinary symptoms. The studied polymorphism was detected by restriction fragment length polymorphism analysis. The χ2 test was used to compare categoric data, with a significance level of 5%. Numeric data were compared with the use of the parametric t test or nonparametric Mann-Whitney U test.
Results |
The distribution of the polymorphism in the investigated women was digested homozygous T allele 69.75%, heterozygotes 29.8%, and homozygous A allele 0.45%. A comparison between the groups showed higher prevalence of the digested homozygous T allele genotype in women with OAB syndrome (P = .001). Multiple logistic regression analysis identified that a family history of OAB syndrome was an independent risk factor for OAB syndrome.
Conclusion |
The Trp 64 Arg polymorphism was associated with OAB syndrome in the Brazilian population.
Le texte complet de cet article est disponible en PDF.Key words : beta 3-adrenoceptor, overactive bladder, polymorphism
Plan
| Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), São Paulo, Brazil. |
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| Cite this article as: Ferreira CE, Fonseca AM, Silva ID, et al. The relationship between the Trp 64 Arg polymorphism of the beta 3–adrenoceptor gene and idiopathic overactive bladder. Am J Obstet Gynecol 2011;205:82.e10-14. |
Vol 205 - N° 1
P. 82.e10-82.e14 - juillet 2011 Retour au numéro
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