A novel optical method to assess cervical changes during pregnancy and use to evaluate the effects of progestins on term and preterm labor - 19/08/11
Reprints: Robert E. Garfield, PhD, Department of Obstetrics and Gynecology, St. Joseph's Hospital and Medical Center, 445 N 5th St, Phoenix, AZ 85004Résumé |
Objective |
The purpose of this study was to determine whether optical methods can estimate cervix function during pregnancy and whether progestins modify this process.
Study Design |
Photos of the external cervix of timed-pregnant rats were taken every other day from day 13 until postpartum day 5 after daily treatments with vehicle (controls) or progestin treatments (progesterone, subcutaneously or vaginally; 17-alpha-hydroxyprogesterone caproate [17P] and RU-486 subcutaneously, once on day 16). The surface area of the cervix was estimated from photos.
Results |
The surface area of cervix increases throughout pregnancy and reverses after delivery in controls. In the progesterone subcutaneously or 17P subcutaneously groups, increases in surface area are lower (17P group until day 19 only; P < .05). Vaginal progesterone does not prevent surface area increases. Only the progesterone subcutaneously blocked delivery. RU-486 increases the surface area of the cervix (P < .05) during preterm delivery.
Conclusion |
An optical method is useful for quantitative assessment of the cervix and evaluation of agents that modify cervical function.
Le texte complet de cet article est disponible en PDF.Key words : cervix, 17-alpha-hydroxyprogesterone caproate, preterm labor, progesterone, rat
Plan
| Cite this article as: Kuon RJ, Shi SQ, Maul H, et al. A novel optical method to assess cervical changes during pregnancy and use to evaluate the effects of progestins on term and preterm labor. Am J Obstet Gynecol 2011;205:82.e15-20. |
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| Supported by National Institutes of Health Grant R01 HD037480 and the St. Joseph's Foundation at St. Joseph's Hospital and Medical Center, Phoenix, AZ. Ruben Kuon is a medical student at the University of Heildelberg, Germany. |
Vol 205 - N° 1
P. 82.e15-82.e20 - juillet 2011 Retour au numéro
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