Maternal inflammation in spontaneous term labor - 19/08/11
Résumé |
Objective |
The purpose of this study was to examine the association between peripheral markers of maternal inflammation and the onset of term labor.
Study Design |
A nested case-control study was performed with serum that had been collected at routine visits from a cohort of 607 term nulliparous women. Cases (n = 20) labored spontaneously within 48 hours of enrollment, and control subjects (n = 80) labored spontaneously ≥14 days after enrollment. Maternal serum cytokines were determined with the use of standard multiplex protocols. Median levels of interleukin-1, -4, -6, -8, and -10, interferon-γ, and tumor necrosis factor–⍺ were compared with the use of the Mann-Whitney U test. Correlations between cytokine levels and maternal factors were performed (Spearman's rho).
Results |
Median interleukin-1 and -6 and tumor necrosis factor–⍺ levels were significantly higher in cases vs control subjects (0.76 vs 0.31 pg/mL [P < .01]; 2.05 vs 0.95 pg/mL [P = .03]; 0.81 vs 0.51 pg/mL [P = .02], respectively). Latency until delivery was inversely correlated with interleukin-1 and tumor necrosis factor–⍺ (−0.28 [P < .01]; −0.246 [P = .01]), but not with interleukin-6.
Conclusion |
Maternal proinflammatory markers increase before spontaneous term labor.
Le texte complet de cet article est disponible en PDF.Key words : cytokine, inflammation, labor
Plan
| Supported in part by research Grant no. 6-Fy06-311 from the March of Dimes Foundation. |
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| The racing flag logo above indicates that this article was rushed to press for the benefit of the scientific community. |
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| Reprints not available from the authors. |
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| Cite this article as: Unal ER, Cierny JT, Roedner C, et al. Maternal inflammation in spontaneous term labor. Am J Obstet Gynecol 2011;204:223.e1-5. |
Vol 204 - N° 3
P. 223.e1-223.e5 - mars 2011 Retour au numéro
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