Pharmacokinetic Changes in Critical Illness - 19/08/11
Doi : 10.1016/j.ccc.2006.02.011
Bradley A. Boucher, PharmD, BCPS a, b, ⁎ 
, G. Christopher Wood, PharmD, BCPS a, Joseph M. Swanson, PharmD, BCPS a
, G. Christopher Wood, PharmD, BCPS a, Joseph M. Swanson, PharmD, BCPS a a Department of Pharmacy, University of Tennessee Health Science Center, 26 South Dunlap, Room 210, Memphis, TN 38163, USA
b Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
⁎Corresponding author. Department of Pharmacy, University of Tennessee Health Science Center, 26 South Dunlap, Room 210, Memphis, TN 38163
Résumé |
Physiologic alterations in critically ill patients can significantly affect the pharmacokinetics of drugs used in the critically ill patient population. Understanding these pharmacokinetic changes is essential relative to optimizing drug therapy. This article outlines the major differences seen in the absorption, distribution, metabolism, and excretion of drugs in critically ill patients. Important strategies for drug therapy dosing and monitoring in these patients are also addressed.
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© 2006
Elsevier Inc. Tous droits réservés.
Vol 22 - N° 2
P. 255-271 - avril 2006 Retour au numéro
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