Abnormal keratin expression in circumscribed palmar hypokeratosis - 19/08/11
, Itaru Dekio, MD, PhD a, c, Atsushi Fujimoto, MD a, Kaori Kameyama, MD, PhD b, Mitsuo Sakamoto, PhD c, Yoshimi Benno, DVM, PhD c, Masayuki Amagai, MD, PhD a, Takeji Nishikawa, MD, PhD a
Reprint requests: Akira Ishiko, MD, PhD, Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.Tokyo and Saitama, Japan
Abstract |
Background |
Circumscribed palmar or plantar hypokeratosis (CPH) is a rare skin disorder only recently described.
Objective |
To determine the diagnostic features and to provide insight into the pathogenesis of CPH, with analysis of two new Japanese cases.
Methods |
Dermoscopy, immunohistochemistry, electron microscopy, polymerase chain reaction amplification for human papillomavirus (HPV) DNA and 16S microbial rRNA gene profiling were conducted.
Results |
Dermoscopy showed characteristic features using both dry and jelly immersion observation; step-like desquamation and a homogeneous erythema with regularly distributed whitish spots. Immunohistochemistry revealed strong staining with anti-pankeratin antibody (AE1+AE3) and anti-keratin 16 antibody, and decreased expression of keratin 2e. EM revealed a breakage of the corneocytes within their cytoplasm, but structures for cell attachment were intact. HPV and lesion-specific bacteria were not detected.
Limitations |
The number of cases analyzed was two.
Conclusion |
Hyperproliferative epidermal state along with enhanced corneocyte fragility may account for the unique features in CPH.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CPH, EM, HPV, PCR, rRNA
Plan
| Supported in part by Grants-in Aid for Scientific Research (C) (18591258) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Conflicts of interest: None declared. |
Vol 57 - N° 2
P. 285-291 - août 2007 Retour au numéro
Article précédent
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- Jared Jagdeo, Martin A. Weinstock, Michael Piepkorn, Stephen F. Bingham, The Department of Veteran Affairs Topical Tretinoin Chemoprevention Trial Group
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