Preventing intraperitoneal adhesions with atorvastatin and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats - 19/08/11
, Konstantinos D. Ballas, M.D., Ph.D. a, Christos Skouras, M.D. a, Christos Asteriou, M.D. b, Theodoros Kontoulis, M.D. a, Dimitrios Pissas, M.D. a, Apostolos Triantafyllou, M.D. a, Athanasios K. Sakantamis, M.D., Ph.D. a
Corresponding author. Tel.: +30-697-448-1181; fax: +30-231-095-9588Abstract |
Objectives |
The aim of this study was to compare the effectiveness of atorvastatin with the sodium hyaluronate/carboxymethylcellulose (HA/CMC, Seprafilm; Genzyme; Genzyme Biosurgery Corporation, Cambridge, MA) in preventing postoperative intraperitoneal adhesion formation in rats.
Methods |
Sixty Wistar rats underwent a laparotomy, and adhesions A were induced by cecal abrasion. The animals were divided into 4 groups: group 1, control A; group 2, (A + atorvastatin); group 3, (A + HA/CMC), and group 4, (A + atorvastatin + HA/CMC). The atorvastatin (groups 2 and 4) and HA/CMC (groups 3 and 4) were administered intraperitoneally before the abdominal wall was closed. After 14 days, adhesions were classified by 2 independent surgeons.
Results |
The adhesion scores (mean ± standard deviation) for groups 1, 2, 3, and 4 were 2.93 ± .59, 1.85 ± 1.07, 1.80 ± .86, and 1.93 ± .70, respectively. The differences in adhesion scores among all 3 preventive groups (groups 2, 3, and 4) were statistically significant when compared with the control group (P = .005, P = .002, and P = .009, respectively).
Conclusions |
These data suggest that atorvastatin, administered intraperitoneally, is as effective as HA/CMC without an expectable additive effect in preventing postoperative adhesions in rats.
Le texte complet de cet article est disponible en PDF.Keywords : Adhesions, Atorvastatin, Hyaluronate, Carboxymethylcellulose, Seprafilm, Rats
Plan
Vol 200 - N° 1
P. 118-123 - juillet 2010 Retour au numéro
Article précédent
- Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon
- Stefan Fritz, Thilo Hackert, Werner Hartwig, Florian Rossmanith, Oliver Strobel, Lutz Schneider, Katja Will-Schweiger, Mechthild Kommerell, Markus W. Büchler, Jens Werner
- A novel technique for hepaticojejunostomy for nondilated bile ducts: a purse-string anastomosis with an intra-anastomotic biodegradable biliary stent
- Johanna Laukkarinen, Juhani Sand, Jenni Leppiniemi, Minna Kellomäki, Isto Nordback
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?