Correlation Between Angiotensin-converting Enzyme, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in the Vitreous of Eyes With Diabetic Retinopathy - 19/08/11
, Mari Ueki, MD, PhD a, Takatoshi Maeno, MD, PhD a, Midori Maruichi, MD, PhD b, Tetsuya Sugiyama, MD, PhD a, Hidehiro Oku, MD, PhD a, Tsunehiko Ikeda, MD, PhD a, Mizuo Miyazaki, MD, PhD b
Inquiries to Shinji Takai, PhD, Department of Pharmacology, Osaka Medical College, 2-7, Diagaku-machi, Takatsuki City, Osaka 569-8686, Japan; fax: +81-72-684-6518Résumé |
Purpose |
To investigate the involvement of angiotensin-converting enzyme (ACE) with angiogenic factors, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 in the vitreous of eyes with proliferative diabetic retinopathy (PDR).
Design |
Observational case series.
Methods |
Angiotensin-conerting enzyme activity in the vitreous was measured by using a synthetic substrate for ACE. VEGF and MMP-9 concentrations were determined by enzyme-linked immunosorbent assay.
Results |
Vitreous ACE activity was significantly higher in eyes with PDR (1.4 ± 1.3 mU/ml) than in eyes with macular holes (0.22 ± 0.11 mU/ml). Vitreous VEGF concentration in the eyes with PDR (1067 ± 1076 pg/ml) was significantly higher than in eyes with macular holes (34 ± 5.5 pg/ml). Vitreous MMP-9 concentration was also significantly higher in eyes with PDR (7.5 ± 3.8 ng/ml) than in eyes with macular holes (4.2 ± 1.4 ng/ml). Significant correlations between ACE and VEGF (P < .01) and between ACE and MMP-9 (P < .01) were observed in the vitreous of eyes with PDR.
Conclusions |
Angiotensin-converting enzyme was significantly correlated with angiogenic factors, VEGF and MMP-9, in the vitreous of eyes with PDR.
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Vol 141 - N° 1
P. 129 - janvier 2006 Retour au numéro
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