ProCGlobal and endogenous thrombin potential during pregnancy - 19/08/11
Reprints: Sabine Eichinger, MD, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, AustriaRésumé |
Objective |
Pregnancy is a hypercoagulable state. We evaluated global markers of coagulation activation, ProCGlobal (Siemens Healthcare Diagnostics, Eschborn, Germany) and endogenous thrombin potential (ETP), in pregnant women with and without low-molecular-weight (LMW) heparin prophylaxis.
Study Design |
We prospectively followed 113 healthy women and 61 women receiving LMW heparin prophylaxis throughout pregnancy. ProCGlobal and ETP were measured in venous blood during the first, second, and third trimester.
Results |
ProCGlobal decreased significantly throughout pregnancy in all women and was lower in anticoagulated women (P < .001 for all comparisons). ETP levels remained unchanged until the third trimester and then significantly decreased in all women. ETP was higher in anticoagulated women than in healthy women at all time points.
Conclusion |
ProCGlobal levels decrease throughout pregnancy. In pregnant women at high thrombotic risk, coagulation activation reflected by low ProCGlobal and high ETP levels is substantial despite LMW heparin prophylaxis.
Le texte complet de cet article est disponible en PDF.Key words : endogenous thrombin potential, low-molecular-weight heparin, pregnancy, ProCGlobal
Plan
| Assays for the determination of endogenous thrombin potential and ProCGlobal were donated by Siemens Healthcare Diagnostics, Eschborn, Germany. |
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| Cite this article as: Hron G, Kyrle PA, Kaider A, et al. ProCGlobal and endogenous thrombin potential during pregnancy. Am J Obstet Gynecol 2010;203:463.e1-6. |
Vol 203 - N° 5
P. 463.e1-463.e6 - novembre 2010 Retour au numéro
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