Factors associated with small head circumference at birth among infants born before the 28th week - 19/08/11
ELGAN Study Investigators
Résumé |
Objective |
We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns.
Study Design |
Demographic, clinical, and placental characteristics of 1445 infants born before the 28th week were gathered and evaluated for their relationship with congenital microcephaly.
Results |
Almost 10% of newborns (n = 138), rather than the expected 2.2%, had microcephaly defined as a head circumference >2 SD below the median. In multivariable models, microcephaly was associated with nonwhite race, severe intrauterine growth restriction, delivery for preeclampsia, placental infarction, and being female. The risk factors for a head circumference between <1 and >2 SD below the median were similar to those of microcephaly.
Conclusion |
Characteristics associated with fetal growth restriction and preeclampsia are among the strongest correlates of microcephaly among children born at extremely low gestational ages. The elevated risk of a small head among nonwhites and females might reflect the lack of appropriate head circumference standards.
Le texte complet de cet article est disponible en PDF.Key words : extreme prematurity, head size, intrauterine growth restriction, microcephaly
Plan
| The ELGAN project was supported by National Institutes of Health, National Institute of Neurologic Diseases and Stroke (U01 NS 400069-01). Dr McElrath was supported by the Women's Reproductive Health Research program, National Institutes of Child Health and Development (K12 HDO1255). |
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| Cite this article as: McElrath TF, Allred EN, Kuban K, et al. Factors associated with small head circumference at birth among infants born before the 28th week. Am J Obstet Gynecol 2010;203:138.e1-8. |
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| Reprints not available from the authors. |
Vol 203 - N° 2
P. 138.e1-138.e8 - août 2010 Retour au numéro
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