Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity - 19/08/11
Résumé |
Objective |
The aim of this study was to determine whether sonographic fetal pulmonary artery flow velocity waveforms correlate with amniotic fluid biomarkers of fetal lung maturity.
Study Design |
We studied women with singleton pregnancies undergoing clinically indicated amniocentesis for fetal lung maturity at Yale-New Haven Hospital. Fetal pulmonary artery flow velocity measurements, including systolic/diastolic ratio, pulsatility index, resistance index, and acceleration-time/ejection-time ratio were obtained using spectral Doppler ultrasound. Pearson's correlation coefficient was used to determine the association between fetal pulmonary artery flow velocity parameters and the lecithin/sphingomyelin ratio.
Results |
Twenty-nine subjects met study criteria. The acceleration-time/ejection-time ratio was inversely correlated with the lecithin/sphingomyelin ratio (r = −0.76; P ≤ .001). This relationship was maintained after controlling for potential confounders. Other fetal pulmonary artery flow velocity measurements were not associated with the lecithin/sphingomyelin ratio.
Conclusion |
There is an inverse correlation between the acceleration-time/ejection-time ratio in the fetal pulmonary artery and the amniotic fluid lecithin/sphingomyelin ratio. This suggests that ultrasound evaluation of fetal pulmonary artery blood flow may be a promising new noninvasive technique to evaluate fetal lung maturity.
Le texte complet de cet article est disponible en PDF.Key words : fetal lung maturity, fetal pulmonary artery flow velocity, lecithin/sphingomyelin ratio, respiratory distress syndrome
Plan
| Reprints not available from the authors. |
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| Cite this article as: Azpurua H, Norwitz ER, Campbell KH, et al. Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity. Am J Obstet Gynecol 2010;203:40.e1-8. |
Vol 203 - N° 1
P. 40.e1-40.e8 - juillet 2010 Retour au numéro
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