A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia - 19/08/11
, Roberto Romero, MD a, b, e, Adi L. Tarca, PhD a, c, Juan Pedro Kusanovic, MD a, b, Francesca Gotsch, MD a, Pooja Mittal, MD a, b, Sun Kwon Kim, MD, PhD a, d, Edi Vaisbuch, MD a, b, Shali Mazaki-Tovi, MD a, b, Offer Erez, MD a, b, Zhong Dong, PhD a, Chong Jai Kim, MD, PhD a, d, Lami Yeo, MD a, b, Sonia S. Hassan, MD a, b
Reprints: Tinnakorn Chaiworapongsa, MD, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Wayne State University/Hutzel Women's Hospital, 3990 John R, Box 4, Detroit, MI 48201Résumé |
Objective |
The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia.
Study Design |
A longitudinal study was conducted in normal pregnant women (n = 160) and patients with preeclampsia (n = 40). Blood samples were collected at 7 gestational age intervals from 6 weeks to term. Plasma concentrations of sVEGFR-2 were determined by enzyme-linked immunosorbent assay. Analysis was performed with cross-sectional and longitudinal (mixed effects model) approaches.
Results |
Mothers destined to develop preeclampsia have lower plasma sVEGFR-2 concentrations than those who will have a normal pregnancy (longitudinal approach; P < .05). Cross-sectional analysis suggested that the median plasma sVEGFR-2 concentration in women destined to develop preeclampsia was significantly lower than that in normal pregnant women from 28-31 weeks of gestation (P = .001) or 6-10 weeks prior to the diagnosis (P < .001).
Conclusion |
A lower maternal plasma sVEGFR-2 concentration precedes the development of preeclampsia, both term and preterm.
Le texte complet de cet article est disponible en PDF.Key words : angiogenesis, biomarker, longitudinal study, mechanisms of disease, pregnancy-induced hypertension
Plan
| This research was supported, in part, by the Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services. |
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| Cite this article as: Chaiworapongsa T, Romero R, Tarca AL, et al. A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia. Am J Obstet Gynecol 2010;202:550.e1-10. |
Vol 202 - N° 6
P. 550.e1-550.e10 - juin 2010 Retour au numéro
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