Histologic Study of Urethral Extracellular Matrix and Collagen From Aging and Long-Term Alloxan-induced Diabetic Male Rats - 20/08/11
, Haylton J. Suaid a, Valeria P. Fazan a, Rodolfo B. Reis a, Adauto J. Cologna a, Silvio Tucci a, Marcelo F. Cassini a, Milton C. Foss b, Antonio Carlos P. Martins c
Reprint requests: Antonio Antunes Rodrigues, Jr., M.D., Ph.D., Department of Anatomy and Surgery, University of São Paulo Faculty of Medicine of Ribeirão Preto, Av Bandeirantes 3900, Campus Universitario, Ribeirao Preto, SP 14048 900 BrazilRésumé |
Objectives |
To evaluate the histological alterations of extracellular matrix in long-term alloxan-induced diabetes and aging urethras of male rats with descriptions of total connective tissue, muscle layer and collagen types I and III relative amounts.
Methods |
Histologic evaluations were performed in 3 animal groups: group 1, 8 weeks old; group 2, 44 weeks old; and group 3, 44 weeks old with alloxan-induced diabetes. The muscle layer thickness, extracellular matrix fibrosis, and collagen were quantified on digital images of the urethral samples.
Results |
A higher total thickness and muscle layer thickness and higher connective tissue and collagen content were observed in the urethras of group 3. No changes in the collagen type III/I ratio were found in the urethra of groups 2 and 3.
Conclusions |
Our results suggest that the morphologic alterations of the urethra should also be considered in long-term studies of diabetic lower urinary tract dysfunction. These morphologic alterations due to diabetes differ from the changes induced by aging itself and could represent a final stage in decompensate urethras. Further studies are necessary to establish the real influence of the urethral morphologic changes on lower urinary tract diabetes dysfunction.
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Vol 77 - N° 2
P. 510.e6-510.e11 - février 2011 Retour au numéro
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