The importance of the shark species as ambassadors for the ocean ecosystems within public aquariums, and an ever increasing understanding of their importance as keystone species in those ecosystems, has resulted in more and more opportunities for the veterinary profession to interact with these charismatic fish. Although still in its infancy in aquatic medicine, endoscopy has the potential to be a valuable tool in the management of captive and free-ranging sharks. When contemplating an endoscopic procedure in a shark, the clinician must consider the unique anatomy of the species, the nature of the immobilization planned, and the performance of the procedure itself. Endoscopy should be considered as an adjunct procedure in the clinical management of captive sharks, and may have an important role in the scientific monitoring of free-ranging shark populations.