Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea - 20/08/11

Doi : 10.1016/j.smrv.2005.04.004

Carol M. Baldwin ^a,^b,^⁎ , Richard R. Bootzin ^c,^{^{1
Tel.: +1 520 621 5705; fax: +1 520 621 9306.}} , Dawn C. Schwenke ^b,^d,^{^{2
Tel.: +1 602 277 5551x5551; fax: +1 602 200 2302.}} , Stuart F. Quan ^e,^{^{3
Tel.: +1 520 626 6115; fax: +1 520 626 6970.}}
^a College of Nursing, Arizona State University (Southwest Borderlands), P.O. Box 872602, Tempe, AZ 85287-2602, USA
^b Carl T. Hayden VA Medical Center, 650 E. Indian School Road, Phoenix, AZ 85012-1892, USA
^c Department of Psychology, University of Arizona, Box 210068, Tucson, AZ 85721-0068, USA
^d W.P. Carey School of Health Management and Policy, Arizona State University, Tempe, AZ, USA
^e Sleep and Arizona Respiratory Centers, 1501 North Campbell Avenue, Tucson, AZ 85724-5030, USA

Corresponding author. Address: College of Nursing, Arizona State University (Southwest Borderlands), P.O. Box 872602, Tempe, AZ 85287-2602, USA. Tel.: +1 480 965 6434; fax: +1 480 965 0212.

Summary

Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlying mechanism(s) for the cognitive deficits and CVD in OSA. A number of studies have suggested that increased levels of oxidative stress and/or antioxidant deficiencies may also be risk factors in cognitive decline and CVD. The influence of antioxidant nutrients and supplements, such as Vitamins B6, B12, C, E, folic acid, alpha-lipoic acid and Coenzyme Q₁₀ on cognitive decline and CVD have been investigated. The influence of antioxidant nutrients or supplements on OSA remains to be investigated. Even if dietary or supplemental antioxidants do not prove to be effective therapies for OSA, dietary assessment and prescription to increase dietary intake of neuro- and cardio-protective nutrients may make it possible to reduce some of the cognitive and cardiovascular sequelae associated with OSA.

Le texte complet de cet article est disponible en PDF.

Keywords : Alpha-lipoic acid, Antioxidants, Cardiovascular disease, Coenzyme Q₁₀, Cognitive deficits, Cytokines, Homocysteine, Nutrient intake, Obstructive sleep apnea, Oxidative stress

Plan

Export

Vol 9 - N° 6

P. 459-476 - décembre 2005 Retour au numéro

Article précédent

Ethnicity and obstructive sleep apnoea
Anna Tessa C. Villaneuva, Peter R. Buchanan, Brendon J. Yee, Ronald R. Grunstein

| Article suivant

Endozepines in recurrent stupor
Pietro Cortelli, Rossella Avallone, Mario Baraldi, Maria Luisa Zeneroli, Jessica Mandrioli, Lorenzo Corsi, Roberto Riva, Paolo Tinuper, Elio Lugaresi, Agostino Baruzzi, Pasquale Montagna

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea - 20/08/11

Summary

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL