Hypothalamic-Pituitary-Adrenal Axis in Rheumatoid Arthritis - 20/08/11
, Jozef Rovenský, MD, DSc, FRCP cRésumé |
The hypothalamic-pituitary-adrenal (HPA) system is a powerful neuroendocrine control mechanism involved in many core body functions including metabolic and energy homeostasis. The HPA axis has been considered an important immune modulator primarily in view of potent anti-inflammatory effects of cortisol in high physiologic and pharmacologic doses. This article describes HPA’s role in rheumatoid arthritis.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Hypothalamic-pituitary-adrenal axis, Cortisol, Dehydroepiandrosterone, Adrenocorticotropic hormone, Corticotropin-releasing hormone, Inflammation, Interleukin-6
Plan
| This work was supported by grants VEGA 2/0187/09, RASGENAS N00024, NFM/EEA grant SK0095 and CENDO SAV. The authors have nothing to disclose. |
Vol 36 - N° 4
P. 721-727 - novembre 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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