Lessons learnt from structural studies of the oestrogen receptor - 20/08/11
: Wellcome Trust Career Development Fellow
Corresponding author. Tel.: +44 1904 328271; Fax: +44 1904 328266.Abstract |
Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptors have provided a wealth of information on the nature of ligand-binding and its role in receptor activation. This review examines the insights that studies on oestrogen receptor subtypes ER⍺ and ERβ have provided in terms of (1) basis of receptor activation; (2) recruitment of coregulators; (3) hormone recognition; and (4) subtype-selective ligands. It also highlights the implications for the binding of endocrine disruptors.
Le texte complet de cet article est disponible en PDF.Key words : receptor agonist, antagonist, protein structure, selective oestrogen receptor modulator, SERM, activation function 2, ligand-binding domain
Plan
Vol 20 - N° 1
P. 1-14 - mars 2006 Retour au numéro
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- Strengths and weaknesses of in vitro assays for estrogenic and androgenic activity
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